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J Math Biol. 2014 Jan;68(1-2):145-79. doi: 10.1007/s00285-012-0621-y. Epub 2012 Nov 20.

DNA topology in chromosomes: a quantitative survey and its physiological implications.

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1
Laboratoire de Physique Théorique de la Matière Condensée, CNRS UMR 7600, and CNRS GDR 3536, Université Pierre et Marie Curie, Case courrier 121, 4 place Jussieu, 75252 , Paris, France, barbi@lptmc.jussieu.fr.

Abstract

Using a simple geometric model, we propose a general method for computing the linking number of the DNA embedded in chromatin fibers. The relevance of the method is reviewed through the single molecule experiments that have been performed in vitro with magnetic tweezers. We compute the linking number of the DNA in the manifold conformational states of the nucleosome which have been evidenced in these experiments and discuss the functional dynamics of chromosomes in the light of these manifold states.

PMID:
23179130
DOI:
10.1007/s00285-012-0621-y
[Indexed for MEDLINE]
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