Format

Send to

Choose Destination
Hear Res. 2013 Mar;297:91-8. doi: 10.1016/j.heares.2012.11.010. Epub 2012 Nov 20.

Changes in the adult vertebrate auditory sensory epithelium after trauma.

Author information

1
Virginia Merrill Bloedel Hearing Research Center, Department of Otolaryngology-Head and Neck Surgery, CHDD CD176, Box 357923, Univ. of Washington, Seattle, WA 98195-7923, USA. oesterle@uw.edu

Abstract

Auditory hair cells transduce sound vibrations into membrane potential changes, ultimately leading to changes in neuronal firing and sound perception. This review provides an overview of the characteristics and repair capabilities of traumatized auditory sensory epithelium in the adult vertebrate ear. Injured mammalian auditory epithelium repairs itself by forming permanent scars but is unable to regenerate replacement hair cells. In contrast, injured non-mammalian vertebrate ear generates replacement hair cells to restore hearing functions. Non-sensory support cells within the auditory epithelium play key roles in the repair processes.

PMID:
23178236
PMCID:
PMC3637947
DOI:
10.1016/j.heares.2012.11.010
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center