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Cell. 2012 Nov 21;151(5):929-31. doi: 10.1016/j.cell.2012.11.007.

Designing an enhancer landscape.

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Division of Hematology/Oncology, Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, USA.


In this issue and in a recent issue of Cell, Vahedi et al. and Samstein et al. provide new insights into the strategies used to establish an enhancer landscape during development of cell lineages. They report that enhancer landscapes characterizing T cell lineages are pre-established and strongly influenced by environmental stimuli.

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