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Diagn Microbiol Infect Dis. 2013 Feb;75(2):210-3. doi: 10.1016/j.diagmicrobio.2012.10.017. Epub 2012 Nov 22.

Update on the prevalence and genetic characterization of NDM-1-producing Enterobacteriaceae in Indian hospitals during 2010.

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JMI Laboratories, North Liberty, IA 52317, USA.


Thirteen NDM-1-producing Enterobacteriaceae, representing all carbapenem-resistant strains (5.2% overall) collected in 3 Indian hospitals during 2010, were analyzed. Eleven genetically distinct strains of 4 bacterial species were observed. All 3 E. coli strains belonged to ST101. Strains harbored bla(CTX-M-15) and at least 1 other β-lactamase. Fluoroquinolone and aminoglycoside resistance genes were detected in 11 and 6 strains, respectively. bla(NDM-1) was carried in plasmids of various sizes and incompatibility types, and 3 were transferred by conjugation. This study confirms the ability of bla(NDM-1) to disseminate among different bacterial species and the genetic variability of the structures carrying this metallo-β-lactamase gene in India.

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