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Biochem Soc Trans. 2012 Dec 1;40(6):1373-7. doi: 10.1042/BST20120168.

Rab GTPase localization and Rab cascades in Golgi transport.

Author information

1
Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305-5307, USA. pfeffer@stanford.edu

Abstract

Rab GTPases are master regulators of membrane traffic. By binding to distinct sets of effector proteins, Rabs catalyse the formation of function-specifying membrane microdomains. They are delivered to membranes by a protein named GDI (guanine-nucleotide-dissociation inhibitor) and are stabilized there after nucleotide exchange by effector binding. In the present mini-review, I discuss what we know about how Rab GTPases are delivered to the correct membrane-bound compartments and how Rab GTPase cascades order Rabs within the secretory and endocytic pathways. Finally, I describe how Rab cascades may establish the distinct compartments of the Golgi complex to permit ordered processing, sorting and secretion of secretory cargoes.

PMID:
23176483
PMCID:
PMC4711396
DOI:
10.1042/BST20120168
[Indexed for MEDLINE]
Free PMC Article

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