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Postepy Hig Med Dosw (Online). 2012 Nov 13;66:818-27. doi: 10.5604/17322693.1019530.

[Risk factors for skin cancer development in patients after organ transplantation].

[Article in Polish]

Author information

1
Oddział Dermatologii Pomorskiego Centrum Traumatologii im. Mikołaja Kopernika w Gdańsku, ul. Nowe Ogrody 1-6, 80-803 Gdańsk, Poland. bimko@wp.pl

Abstract

Cancer has become the second most common cause of death in patients after organ transplantation. Among all cancers arising de novo after transplantation skin cancers are the most common, accounting for 95% of all skin neoplasms. Due to the significantly higher morbidity, aggressive, rapid progression of cancer and unfavorable prognosis, the population requires a specific oncological approach. Therefore, special attention should be paid to factors predisposing to the development of cancer, including skin cancer, in patients after organ transplantation. Some of these factors are well understood, while the role of others is still ambiguous. Among the etiological factors mentioned are those that are associated with the recipient. These include genetic factors such as male sex, fair skin and inability to be tanned, and compatibility of the HLA system, and non genetic factors such as patient age, chronic skin ulcers and scars, the type of transplanted organ, immunosuppression, and particularly the type and cumulative doses of drugs. In addition, the pathogenesis of cancer is influenced by environmental factors such as exposure to sunlight and therefore latitude, ionizing radiation, chemical carcinogens and viral infections. Knowledge of etiological factors and mechanisms of etiopathogenesis allow for indication and observation of patients with increased risk of cancer as well as faster healing in these patients.

PMID:
23175337
DOI:
10.5604/17322693.1019530
[Indexed for MEDLINE]
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