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Nat Rev Cancer. 2012 Dec;12(12):877-86. doi: 10.1038/nrc3400.

Human tumour viruses and the deregulation of cell polarity in cancer.

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1
The International Centre for Genetic Engineering and Biotechnology, Padriciano 99, I-34149 Trieste, Italy. Banks@icgeb.org

Abstract

The role of cell polarity regulators in the development of cancer has long been an enigma. Despite displaying characteristics of tumour suppressors, the core regulators of polarity are rarely mutated in tumours and there are few data from animal models to suggest that they directly contribute to cancer susceptibility, thus questioning their relevance to human carcinogenesis. However, a body of data from human tumour viruses is now providing compelling evidence of a central role for the perturbation of cell polarity in the development of cancer.

PMID:
23175122
DOI:
10.1038/nrc3400
[Indexed for MEDLINE]
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