Schematic representations of the most frequently targeted, novel candidate genes in medulloblastoma. Mutation positions are based on the three next-generation sequencing studies described in the text-. Genes are depicted within the subgroup for which they show the greatest enrichment. In Group 3, the zoom box adjacent to MYC depicts the general structure of the recurrent PVT1-MYC fusion genes reported by Northcott et al. In Group 4, the zoom box adjacent to SNCAIP illustrates the general structure of the SNCAIP tandem duplications described by Northcott et al. Abbreviations: DEAD, DEAD domain; LIM, LIM domain; ANK, ankyrin repeat; HLH, helix-loop-helix domain; NIF, NLI interacting factor-like phosphatase; TPR, tetratricopeptide repeat; JmjC, Jumonji C domain; InDel, insertion/deletion.