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Am J Obstet Gynecol. 2012 Dec;207(6):504.e1-5. doi: 10.1016/j.ajog.2012.09.027. Epub 2012 Oct 1.

Performance of an automatic quantitative ultrasound analysis of the fetal lung to predict fetal lung maturity.

Author information

1
Department of Maternal-Fetal Medicine, Institut Clínic de Ginecologia, Obstetrícia i Neonatologia, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain.

Abstract

OBJECTIVE:

The objective of the study was to evaluate the performance of automatic quantitative ultrasound analysis (AQUA) texture extractor to predict fetal lung maturity tests in amniotic fluid.

STUDY DESIGN:

Singleton pregnancies (24.0-41.0 weeks) undergoing amniocentesis to assess fetal lung maturity (TDx fetal lung maturity assay [FLM]) were included. A manual-delineated box was placed in the lung area of a 4-chamber view of the fetal thorax. AQUA transformed the information into a set of descriptors. Genetic algorithms extracted the most relevant descriptors and then created and validated a model that could distinguish between mature or immature fetal lungs using TDx-FLM as a reference.

RESULTS:

Gestational age at enrollment was (mean [SD]) 32.2 (4.5) weeks. According to the TDx-FLM results, 41 samples were mature and 62 were not. The imaging biomarker based on AQUA presented a sensitivity 95.1%, specificity 85.7%, and an accuracy 90.3% to predict a mature or immature lung.

CONCLUSION:

Fetal lung ultrasound textures extracted by AQUA provided robust features to predict TDx-FLM results.

PMID:
23174391
DOI:
10.1016/j.ajog.2012.09.027
[Indexed for MEDLINE]

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