Send to

Choose Destination
Neurosurg Clin N Am. 2013 Jan;24(1):79-88. doi: 10.1016/ Epub 2012 Oct 10.

Skull base chordomas: clinical features, prognostic factors, and therapeutics.

Author information

Department of Neurological Surgery, University of California, San Francisco, CA 94143, USA.


Chordomas of the skull base are one of the rarest intracranial malignancies that arise from ectopic remnants of embryonal notochod. The proximity of many chordomas to neurovascular structures makes gross total resection difficult, and the tendency for recurrence leads to the routine use of adjuvant postoperative radiation. Several surgical approaches are used ranging from extensive craniotomies to minimally invasive endonasal endoscopic approaches. In this review, the histopathology and epidemiology, imaging characteristics, surgical approaches, adjuvant therapies, prognostic factors, and molecular biology of chordomas are described.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center