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BMC Surg. 2012;12 Suppl 1:S15. doi: 10.1186/1471-2482-12-S1-S15. Epub 2012 Nov 15.

Use of statins in lower extremity artery disease: a review.

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1
Department of Clinical Medicine and Cardiovascular and Immunology Sciences, Federico II University, via Pansini 5, 80131 Naples, Italy.

Abstract

BACKGROUND:

Lower extremity artery disease (LE-PAD) is one of the most common manifestations of atherosclerosis, particularly in elderly patients, and it is related to a high cardiovascular risk.

DESCRIPTION:

It is well established that statin therapy is characterized by crucial benefits on cardiovascular system by limiting atherosclerotic progression and reducing cardiovascular events and mortality. A growing body of evidence support efficacy of statins in LE-PAD due to the ability of both reducing cardiovascular risk and improving walking distance and, hence, quality of life. Consequently, statin therapy should be considered in all LE-PAD patients and new LDL-cholesterol targets should be reached.

CONCLUSIONS:

Our opinion is that statin therapy remains still underutilized or with inadequate dosage, so therapy of LE-PAD patients should be improved to obtain all the demonstrated benefits of statins.

PMID:
23173874
PMCID:
PMC3499199
DOI:
10.1186/1471-2482-12-S1-S15
[Indexed for MEDLINE]
Free PMC Article
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