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Expert Opin Ther Targets. 2013 Jan;17(1):21-8. doi: 10.1517/14728222.2012.732066. Epub 2012 Nov 22.

miR-210: a therapeutic target in cancer.

Author information

1
Fourth Military Medical University, Xijing Hospital of Digestive Diseases, Xijing Hospital, State Key Laboratory of Cancer Biology, Xi'an, 710032, Shaanxi Province, China. hongliu180@126.com

Abstract

INTRODUCTION:

As the predominant miRNA regulated by hypoxia, miR-210 correlates with survival in cancer patients. miR-210 may play important roles in regulation of cell growth, angiogenesis and apoptosis in different human tumor models, indicating that it can be used as a therapeutic target.

AREAS COVERED:

This review covers all literature related to miR-210 in malignant tumors from the past 5 years, and analyzes the biological functions and molecular mechanisms of it. The authors also envisage future developments toward the clinical applications of miR-210 to cancer diagnosis and treatment.

EXPERT OPINION:

miR-210 may function as a new therapeutic target for anticancer intervention. Considering that the exact function of miR-210 is still not well characterized and understood, more investigations should be performed to promote the success of therapeutic-clinical use of miR-210 in cancer.

PMID:
23173806
DOI:
10.1517/14728222.2012.732066
[Indexed for MEDLINE]
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