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Neurocase. 2014;20(1):100-9. doi: 10.1080/13554794.2012.732089. Epub 2012 Nov 22.

Neuropsychological, behavioral, and anatomical evolution in right temporal variant frontotemporal dementia: a longitudinal and post-mortem single case analysis.

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1
a Memory and Aging Center, Department of Neurology , University of California San Francisco , San Francisco , CA , USA.

Abstract

We describe a patient with semantic variant of frontotemporal dementia who received longitudinal clinical evaluations and structural MRI scans and subsequently came to autopsy. She presented with early behavior changes and semantic loss for foods and people and ultimately developed a pervasive semantic impairment affecting social-emotional as well as linguistic domains. Imaging revealed predominant atrophy of the right temporal lobe, with later involvement of the left, and pathology confirmed bilateral temporal involvement. Findings support the view that left and right anterior temporal lobes serve as semantic hubs that may be affected differentially in semantic variant by early, relatively unilateral damage.

PMID:
23171151
PMCID:
PMC3775867
DOI:
10.1080/13554794.2012.732089
[Indexed for MEDLINE]
Free PMC Article
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