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Oncoimmunology. 2012 Oct 1;1(7):1208-1210.

Specificity may be overrated in cancer immunotherapy: Getting to know the nonspecific side of memory T Cells.

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  • 1Department of Dermatology; University of California; Davis School of Medicine; Sacramento, CA USA.

Abstract

For a long time, cancer immunotherapy has focused on the induction of tumor-specific T cell-mediated immune responses. Now, a mounting body of evidence indicates that efficient anticancer immune responses also rely on innate immunity. Tietze et al. have recently elucidated an antigen-nonspecific role for memory CD8(+) T cells in cytokine-based cancer immunotherapy.

PMID:
23170282
PMCID:
PMC3494648
DOI:
10.4161/onci.20779
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