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Oncoimmunology. 2012 Oct 1;1(7):1191-1193.

Targeting the right regulatory T-cell population for tumor immunotherapy.

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1
The Sidney Kimmel Cancer Center; Johns Hopkins University School of Medicine; Baltimore, MD USA ; Department of Oncology; Johns Hopkins University School of Medicine; Baltimore, MD USA ; Graduate Program in Immunology; Johns Hopkins School of Medicine; Baltimore, MD USA.

Abstract

Regulatory T cells (Tregs) that suppress tumor-specific T cell-mediated immune responses are the subject of an intense wave of investigation. We recently reported that a subset of Tregs, namely effector/memory CD25(low) cells, are responsible for suppressing high avidity tumor-specific T cells in mouse mammary tumors. Here, we discuss additional findings that clarify this mechanism of Treg-mediated immunosuppression.

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