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Viruses. 2012 Sep;4(9):1438-76. doi: 10.3390/v4091438. Epub 2012 Sep 3.

Evasion of influenza A viruses from innate and adaptive immune responses.

Author information

1
Department of Virology, ErasmusMC, Dr. Molewaterplein 50, 3015 GE, Rotterdam, The Netherlands. c.vandesandt@erasmusmc.nl

Abstract

The influenza A virus is one of the leading causes of respiratory tract infections in humans. Upon infection with an influenza A virus, both innate and adaptive immune responses are induced. Here we discuss various strategies used by influenza A viruses to evade innate immune responses and recognition by components of the humoral and cellular immune response, which consequently may result in reduced clearing of the virus and virus-infected cells. Finally, we discuss how the current knowledge about immune evasion can be used to improve influenza A vaccination strategies.

KEYWORDS:

adaptive immunity; evasion; influenza; innate immunity

PMID:
23170167
PMCID:
PMC3499814
DOI:
10.3390/v4091438
[Indexed for MEDLINE]
Free PMC Article

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