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Muscle Nerve. 2013 Feb;47(2):230-40. doi: 10.1002/mus.23499. Epub 2012 Nov 21.

Tongue muscle plasticity following hypoglossal nerve stimulation in aged rats.

Author information

1
Department of Surgery, Otolaryngology-Head and Neck Surgery, 600 Highland Avenue, Room K4/711, University of Wisconsin, Madison, Wisconsin 53792, USA. connor@surgery.wisc.edu

Abstract

INTRODUCTION:

Age-related decreases in tongue muscle mass and strength have been reported. It may be possible to prevent age-related tongue muscle changes using neuromuscular electrical stimulation (NMES). Our hypothesis was that alterations in muscle contractile properties and myosin heavy chain composition would be found after NMES.

METHODS:

Fifty-four young, middle-aged, and old 344/Brown Norway rats were included in this study. Twenty-four rats underwent bilateral electrical stimulation of the hypoglossal nerves for 8 weeks and were compared with control or sham rats. Muscle contractile properties and myosin heavy chain (MHC) in the genioglossus (GG), styloglossus (SG), and hyoglossus (HG) muscles were examined.

RESULTS:

Compared with unstimulated control rats, we found reduced muscle fatigue, increased contraction and half-decay times, and increased twitch and tetanic tension. Increased type I MHC was found, except for in GG in old and middle-aged rats.

CONCLUSION:

Transitions in tongue muscle contractile properties and phenotype were found after NMES.

PMID:
23169566
PMCID:
PMC3556192
DOI:
10.1002/mus.23499
[Indexed for MEDLINE]
Free PMC Article
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