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J Alzheimers Dis. 2013;34(1):139-44. doi: 10.3233/JAD-121861.

You don't say: dynamic aphasia, another variant of primary progressive aphasia?

Author information

1
Department of Neurology, Center for Brain/Mind Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.

Abstract

Primary progressive aphasia (PPA) is a language predominant neurodegenerative disorder that has three recognized variants: nonfluent/agrammatic, semantic, and logopenic. This report describes a 60-year-old man who presented with a progressive decline in verbal output that does not fit the currently accepted PPA subtypes. The patient exhibited a paucity of verbal output and impaired phonemic fluency with minimal associated language, cognitive, or behavioral deficits. Focal cortical thinning/hypometabolism of the left superior frontal region and a cerebrospinal fluid profile not consistent with Alzheimer's disease pathology were identified. This case of isolated progressive dynamic aphasia extends the current boundaries of PPA diagnostic variants.

PMID:
23168447
PMCID:
PMC3621037
DOI:
10.3233/JAD-121861
[Indexed for MEDLINE]
Free PMC Article

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