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Arch Phys Med Rehabil. 2013 Apr;94(4):660-6. doi: 10.1016/j.apmr.2012.11.013. Epub 2012 Nov 17.

Impact of an exercise program on muscular and functional performance and plasma levels of interleukin 6 and soluble receptor tumor necrosis factor in prefrail community-dwelling older women: a randomized controlled trial.

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1
Rehabilitation Science, Universidade Federal de Minas Gerais and Centro Universitário de Belo Horizonte, Belo Horizonte, MG, Brazil.

Abstract

OBJECTIVE:

To examine the impact of a muscle resistance program (MRP) on muscular and functional performance and on interleukin 6 (IL-6) and soluble tumor necrosis factor receptor-1 (sTNFr1) plasma levels in prefrail community-dwelling women.

DESIGN:

Randomized controlled trial crossover design with a postintervention and short-term follow-up.

SETTING:

University hospital.

PARTICIPANTS:

Prefrail community-dwelling women (N=32; ≥65y).

INTERVENTION:

The MRP was designed based on the exercise at 75% of each participant's maximum load (10wk, 3 times/wk).

MAIN OUTCOME MEASURES:

Plasma concentrations of IL-6 and sTNFr1 (high-sensitivity enzyme-linked immunosorbent assay kits), muscle strength of the knee extensors (isokinetic), and functional performance (Timed Up & Go [TUG] test and 10-meter walk test [10MWT]).

RESULTS:

There were significant differences in functional and muscular performance between the pre-MRP, post-MRP, and 10-week follow-up period. After the MRP, both functional (TUG, pre-MRP=11.1s vs post-MRP=10.4s, P=.00; 10MWT, pre-MRP=4.9s vs post-MRP, 4.4s, P=.00) and muscular performances (pre-MRP=77.8% and post-MRP=83.1%, P=.02) improved. After cessation of the MRP (follow-up period), sTNFr1 plasma levels increased by 21.4% at 10-week follow-up (post-MRP, 406.4pg/mL; 10-week follow-up, 517.0pg/mL; P=.03). There were significant differences in sTNFr1 (P=.01).

CONCLUSIONS:

The MRP was effective in improving functional and muscular performances, although alterations in plasma levels of IL-6 and sTNFr1 could not be identified after the MRP. Cessation of the MRP after 10 weeks resulted in increased plasma levels of sTNFr1.

PMID:
23168399
DOI:
10.1016/j.apmr.2012.11.013
[Indexed for MEDLINE]
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