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Tuberc Respir Dis (Seoul). 2012 Aug;73(2):115-21. doi: 10.4046/trd.2012.73.2.115. Epub 2012 Aug 31.

A Case of Pulmonary MALT Lymphoma Arising from Lymphocytic Interstitial Pneumonitis.

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Department of Internal Medicine, Bucheon St. Mary's Hospital, The Catholic University of Korea School of Medicine, Bucheon, Korea.


Pulmonary mucosa-associated lymphoid tissue-derived (MALT) lymphoma is a rare disease. This disorder is considered to be a model of antigen-driven lymphoma, which is driven either by autoantigens or by chronic inflammatory conditions. Low-grade B-cell MALT lymphoma may develop from a nonneoplastic pulmonary lymphoproliferative disorder, such as lymphocytic interstitial pneumonitis (LIP). A recent estimate predicts that less than 5% of LIP patients acquire malignant, low-grade, B-cell lymphoma. In Korea, there has been no previous report of malignant low-grade, B-cell lymphoma, acquired from LIP. Here, we present the case of a patient with LIP that developed into pulmonary MALT lymphoma, six years after diagnosis.


Lung Diseases, Interstitial; Lymphoid Tissue; Lymphoma; Lymphoproliferative Disorders

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