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Clin Infect Dis. 2013 Feb;56(4):e40-7. doi: 10.1093/cid/cis938. Epub 2012 Nov 19.

Diagnosis of acute deer tick virus encephalitis.

Author information

1
Division of Infectious Diseases, New York Medical College, Valhalla, NY 10595, USA. marc_khoury@nymc.edu

Abstract

BACKGROUND:

Deer tick virus (DTV) is a tick-borne flavivirus that has only recently been appreciated as a cause of viral encephalitis. We describe the clinical presentation of a patient who had DTV encephalitis diagnosed before death and survived for 8 months despite severe neurologic dysfunction.

METHODS:

Diagnosis was made from a cerebrospinal fluid specimen, using a flavivirus-specific polymerase chain-reaction assay followed by sequence confirmation, and the phylogeny was analyzed. Serologic testing, including plaque reduction neutralization testing, was also performed.

RESULTS:

Molecular analysis indicated that the virus was closely related to 2 strains of DTV that had been detected in Ixodes scapularis ticks from Massachusetts in 1996 and in the brain of a patient from New York in 2007.

CONCLUSIONS:

DTV encephalitis should be considered in the differential diagnosis of encephalitis in geographic areas that are endemic for Lyme disease.

PMID:
23166187
DOI:
10.1093/cid/cis938
[Indexed for MEDLINE]

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