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Small. 2013 May 27;9(9-10):1696-702. doi: 10.1002/smll.201202001. Epub 2012 Nov 20.

Evaluation of cell function upon nanovector internalization.

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1
Department of Nanomedicine, The Methodist Hospital Research Institute, 6670 Bertner Ave. MS R7-414 Houston, TX 77030, USA.

Abstract

In vitro toxicity assays based on the evaluation and retention of advanced and specific cellular functions are proposed to investigate mesoporous silicon nanovectors. This approach provides greater insight compared to simple cellular viability and toxicity assays. Electron microscopy images demonstrate internalized nanovectors altering the curvature of the nuclear envelope with minimal effect on viability or biological function.

PMID:
23166049
PMCID:
PMC3733230
DOI:
10.1002/smll.201202001
[Indexed for MEDLINE]
Free PMC Article
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