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Biochem Mol Biol Educ. 2012 Nov-Dec;40(6):400-1. doi: 10.1002/bmb.20650. Epub 2012 Oct 13.

Proteopedia: 3D visualization and annotation of transcription factor-DNA readout modes.

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1
Molecular and Computational Biology Program, Departments of Biological Sciences, Chemistry, and Physics and Astronomy, University of Southern California, 1050 Childs Way, Los Angeles, CA 90089, USA.

Abstract

3D visualization assists in identifying diverse mechanisms of protein-DNA recognition that can be observed for transcription factors and other DNA binding proteins. We used Proteopedia to illustrate transcription factor-DNA readout modes with a focus on DNA shape, which can be a function of either nucleotide sequence (Hox proteins) or base pairing geometry (p53). © 2012 by The International Union of Biochemistry and Molecular Biology.

PMID:
23166030
DOI:
10.1002/bmb.20650
[Indexed for MEDLINE]
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