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ACS Chem Biol. 2013 Feb 15;8(2):309-13. doi: 10.1021/cb300520u. Epub 2012 Nov 26.

Chemical detoxification of small molecules by Caenorhabditis elegans.

Author information

1
Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, Florida, USA.

Abstract

Caenorhabditis elegans lives in compost and decaying fruit, eats bacteria and is exposed to pathogenic microbes. We show that C. elegans is able to modify diverse microbial small-molecule toxins via both O- and N-glucosylation as well as unusual 3'-O-phosphorylation of the resulting glucosides. The resulting glucosylated derivatives have significantly reduced toxicity to C. elegans, suggesting that these chemical modifications represent a general mechanism for worms to detoxify their environments.

PMID:
23163740
PMCID:
PMC3747836
DOI:
10.1021/cb300520u
[Indexed for MEDLINE]
Free PMC Article

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