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Oncoimmunology. 2012 Sep 1;1(6):968-970.

Good things come in small packages: Therapeutic anti-tumor immunity induced by microRNA nanoparticles.

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1
Department of Medicine; Weill Cornell Medical College; New York, NY USA ; The Ragon Institute of MGH; MIT and Harvard; Charlestown, MA USA.

Abstract

Current ovarian cancer treatments based on surgery/chemotherapy show limited efficacy. Targeting immunosuppression is a requirement for the effectiveness of novel promising anti-tumor immunotherapies. Our latest work in preclinical models shows that nanoparticle-mediated delivery of immunostimulatory microRNAs specifically to tumor-associated leukocytes is sufficient to re-program immunological control of metastatic ovarian cancers.

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