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Angew Chem Int Ed Engl. 2012 Dec 7;51(50):12438-43. doi: 10.1002/anie.201206797. Epub 2012 Nov 19.

Complex small-molecule architectures regulate phenotypic plasticity in a nematode.

Author information

1
Boyce Thompson Institute and Department of Chemistry, Cornell University, Ithaca, NY, USA.

Abstract

Chemistry the worm's way: The nematode Pristionchus pacificus constructs elaborate small molecules from modified building blocks of primary metabolism, including an unusual xylopyranose-based nucleoside (see scheme). These compounds act as signaling molecules to control adult phenotypic plasticity and dauer development and provide examples of modular generation of structural diversity in metazoans.

PMID:
23161728
PMCID:
PMC3733369
DOI:
10.1002/anie.201206797
[Indexed for MEDLINE]
Free PMC Article

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