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Angew Chem Int Ed Engl. 2012 Dec 21;51(52):13173-7. doi: 10.1002/anie.201206658. Epub 2012 Nov 19.

Imaging mass spectrometry and genome mining reveal highly antifungal virulence factor of mushroom soft rot pathogen.

Author information

1
Department of Biomolecular Chemistry, Leibniz Institute for Natural Product Research and Infection Biology, HKI, Jena, Germany.

Abstract

Caught in the act: imaging mass spectrometry of a button mushroom infected with the soft rot pathogen Janthinobacterium agaricidamnosum in conjunction with genome mining revealed jagaricin as a highly antifungal virulence factor that is not produced under standard cultivation conditions. The structure of jagaricin was rigorously elucidated by a combination of physicochemical analyses, chemical derivatization, and bioinformatics.

PMID:
23161559
DOI:
10.1002/anie.201206658
[Indexed for MEDLINE]

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