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J Renin Angiotensin Aldosterone Syst. 2014 Jun;15(2):162-9. doi: 10.1177/1470320312466126. Epub 2012 Nov 16.

Imidapril provides a protective effect on pulmonary hypertension induced by low ambient temperature in broiler chickens.

Author information

1
Department of Pharmacy, College of Animal Science and Technology, Henan University of Science and Technology, China.
2
Department of Cardiology, Luoyang Central Hospital Affiliated to Zhengzhou University, China zsydoctor@163.com.
3
Luoyang Entry-Exit Inspection and Quarantine Bureau, China.
4
College of Food and Biology Engineering, Department of Biology Engineering, Henan University of Science and Technology, China.
5
Department of Integrated ICU, the First Affiliated Hospital of Zhengzhou University, China.
6
Department of Pharmacology, Zunyi Medical College, China.

Abstract

OBJECTIVE:

The objective of this article is to explore the role of imidapril on pulmonary hypertension induced by low ambient temperature in broiler chickens.

MATERIALS AND METHODS:

Ninety chickens were randomly divided into three groups (n = 30): a control group, a low-temperature group and an imidapril group. Chickens in the low-temperature group and imidapril group were exposed to low ambient temperature from 14 days of age until 45 days of age; chickens in the imidapril group were gavaged with imidapril 3 mg/kg once daily for 30 days. The pulmonary arterial pressure, main pulmonary arterial diameter and pulmonary arterial wall thickness were measured, and lung tissue ACE, ACE2 mRNA expression, proliferating cell nuclear antigen (PCNA)-positive cells and Ang II, Ang (1-7) concentration were evaluated.

RESULTS:

The pulmonary arterial pressure was higher, the main pulmonary arterial diameter was wider and the pulmonary arterial wall was thicker in the low-temperature group than those in the control group and the imidapril group. ACE mRNA and PCNA-positive cells increased significantly in the low-temperature group compared with the control group and imidapril group; lung tissue Ang II concentration in the low-temperature group was higher, but Ang (1-7) content was lower than that in the control group and imidapril group.

CONCLUSION:

Imidapril provides a protective effect on pulmonary hypertension induced by low ambient temperature in broiler chickens.

KEYWORDS:

Imidapril; broiler chicken; pulmonary hypertension; vascular remodeling

PMID:
23161146
DOI:
10.1177/1470320312466126
[Indexed for MEDLINE]
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