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Eur Rev Med Pharmacol Sci. 2012 Nov;16(12):1691-5.

Platelet glycoprotein IaC807T polymorphisms and ischemic stroke in young Chinese Han population.

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1
Department of Neurology, East Hospital, Tongji University School of Medicine, Shanghai, China.

Abstract

OBJECTIVES:

The objective of this study was to investigate the association between platelet glycoprotein (GP) Ia C807T polymorphisms and ischemic stroke in young Chinese Han Population.

MATERIALS AND METHODS:

We conducted a case-control study in 92 consecutive young (</= 50 years) first-ever hospitalized ischemic stroke inpatients and outpatients, 86 elder ischemic stroke control (> 50 years), and 160 age- and sex-matched healthy control. Genotyping of platelet GP Ia C807Tpolymorphisms was performed by polymerase chain reaction followed by sequencing nucleic acid with dideoxy chain-termination method and an ABI PRISM3100 (Perkin-Elmer Co) genetic analyzer. Student's t-test, chi-square test, and logistic regression modeling were used for data significance analyses.

RESULTS:

Hypertension and smoking were found to be the independent risk factors for ischemic stroke patients (aged </= 50 years), while hypertension, diabetes and smoking were the independent risk factors for ischemic stroke patients (aged > 50 years). There was no significant difference observed in the T allele frequency of GPIa C807T polymorphisms between young stroke patients and corresponding controls.

CONCLUSIONS:

These findings suggest that there is no role of GPIa C807T polymorphisms in the development of young first-ever ischemic stroke in Chinese Han Population.

PMID:
23161041
[Indexed for MEDLINE]
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