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J Struct Funct Genomics. 2013 Mar;14(1):19-24. doi: 10.1007/s10969-012-9148-0. Epub 2012 Nov 16.

Solution NMR structure of the helicase associated domain BVU_0683(627-691) from Bacteroides vulgatus provides first structural coverage for protein domain family PF03457 and indicates domain binding to DNA.

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1
Department of Chemistry, The State University of New York at Buffalo, Buffalo, NY 14260, USA.

Abstract

A high-quality NMR structure of the helicase associated (HA) domain comprising residues 627-691 of the 753-residue protein BVU_0683 from Bacteroides vulgatus exhibits an all α-helical fold. The structure presented here is the first representative for the large protein domain family PF03457 (currently 742 members) of HA domains. Comparison with structurally similar proteins supports the hypothesis that HA domains bind to DNA and that binding specificity varies greatly within the family of HA domains constituting PF03457.

PMID:
23160728
PMCID:
PMC3637686
DOI:
10.1007/s10969-012-9148-0
[Indexed for MEDLINE]
Free PMC Article
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