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Nat Immunol. 2012 Dec;13(12):1129-32. doi: 10.1038/ni.2392.

Immunology beats cancer: a blueprint for successful translation.

Author information

1
Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. dpardol1@jhmi.edu

Abstract

Immunology offers an unprecedented opportunity for the science-driven development of therapeutics. The successes of antibodies to the immunomodulatory receptor CTLA-4 and blockade of the immunoinhibitory receptor PD-1 in cancer immunotherapy, from gene discovery to patient benefit, have created a paradigm for driving such endeavors.

PMID:
23160205
PMCID:
PMC4659410
DOI:
10.1038/ni.2392
[Indexed for MEDLINE]
Free PMC Article

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