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Nat Biotechnol. 2012 Dec;30(12):1210-6. doi: 10.1038/nbt.2436. Epub 2012 Nov 25.

Protective efficacy of in vitro synthesized, specific mRNA vaccines against influenza A virus infection.

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1
Institute of Immunology, Friedrich-Loeffler-Institut, Tübingen, Germany.

Abstract

Despite substantial improvements, influenza vaccine production-and availability-remain suboptimal. Influenza vaccines based on mRNA may offer a solution as sequence-matched, clinical-grade material could be produced reliably and rapidly in a scalable process, allowing quick response to the emergence of pandemic strains. Here we show that mRNA vaccines induce balanced, long-lived and protective immunity to influenza A virus infections in even very young and very old mice and that the vaccine remains protective upon thermal stress. This vaccine format elicits B and T cell-dependent protection and targets multiple antigens, including the highly conserved viral nucleoprotein, indicating its usefulness as a cross-protective vaccine. In ferrets and pigs, mRNA vaccines induce immunological correlates of protection and protective effects similar to those of a licensed influenza vaccine in pigs. Thus, mRNA vaccines could address substantial medical need in the area of influenza prophylaxis and the broader realm of anti-infective vaccinology.

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PMID:
23159882
DOI:
10.1038/nbt.2436
[Indexed for MEDLINE]

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