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Toxicol Lett. 1990 Mar;51(1):59-65.

Increased levels of protein- and lipid-bound sialic acids in the renal cortex of rats injected with low doses of gentamicin.

Author information

1
Laboratoire de Chimie Physiologique, Université Catholique de Louvain, Brussels, Belgium.

Abstract

Administration of the aminoglycoside antibiotic, gentamicin, even at therapeutic doses, causes renal lysosomal phospholipidosis. We now report that protein- and lipid-bound sialic acid levels are increased significantly in a time-dependent fashion in the renal cortex of rats injected with gentamicin (10 mg/kg body wt. per day) for 4-10 days and a significant relationship could be observed between these two parameters. This elevation was not due to tissue regeneration, since it was not observed in cisplatin-treated animals.

PMID:
2315959
DOI:
10.1016/0378-4274(90)90225-b
[Indexed for MEDLINE]

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