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Cell Host Microbe. 2012 Nov 15;12(5):605-6. doi: 10.1016/j.chom.2012.11.002.

Poliovirus evolution: the strong, silent type.

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Department of Human Genetics, University of Utah, School of Medicine, Salt Lake City, UT 84112, USA.


The high mutation rates of poliovirus and other RNA viruses promote viral diversity by rapid sampling of mutations. In this issue, Lauring et al. (2012) report that underlying synonymous codon variation in virus populations can have a considerable impact on adaptive potential with implications for viral fitness and virulence.

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