Format

Send to

Choose Destination
See comment in PubMed Commons below
Diabetes Metab Syndr. 2012 Jul-Sep;6(3):140-5. doi: 10.1016/j.dsx.2012.09.010. Epub 2012 Oct 24.

Accumulation of plasma 3-deoxyglucosone impaired glucose regulation in Chinese seniors: implication for senile diabetes?

Author information

1
Institute of Traditional Chinese Medicine, Suzhou Traditional Chinese Medicine Hospital, Suzhou, China.

Abstract

AIMS:

To investigate the impact of increasing accumulation of 3-deoxyglucosone (3-DG) on glucose regulation in non-diabeteic seniors.

METHODS:

This research is a 2-year prospective follow-up study. We conducted a HPLC assay to determine the plasma 3-DG concentrations of 132 non-diabetic retirees of Suzhou. An oral glucose tolerance test was carried out 2 years after baseline in 16 subjects with continual high plasma 3-DG and 16 control subjects randomly sampled in those with normal plasma 3-DG.

RESULTS:

The median plasma 3-DG level of 132 subjects was 43.52 ng/ml (7.89-736.09 ng/ml), of which 47 subjects (36.6%) were beyond 70 ng/ml. A correlation between age and 3-DG was found among people between 50 and 66 years old (r=0.408, P<0.001). The 60-69 years group had a higher 3-DG level than 50-59 years group (P<0.001). Compared with control group, the continual high plasma 3-DG subjects had a higher level of FINs (P<0.05), FBG (P<0.01), HOMA-IR (P<0.001), and a lower level of ISI (P<0.001) and ΔI(60)/ΔG(60) (P<0.05), as well as a higher incidence of impaired glucose regulation (χ(2)=7.814, P<0.05).

CONCLUSIONS:

There was abnormal elevation of plasma 3-DG in non-diabetic seniors, and the increasing accumulation of plasma 3-DG, which mainly resulted from aging, eventually lead to the impaired glucose regulation, indicating an association of 3-DG with senile diabetes.

PMID:
23158977
DOI:
10.1016/j.dsx.2012.09.010
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center