Format

Send to

Choose Destination
See comment in PubMed Commons below
Surg Neurol. 1990 Mar;33(3):213-6.

Alkaptonuric ochronosis and multiple intracranial aneurysms.

Author information

1
Section of Neurosurgery, University of Manitoba, Winnipeg, Canada.

Abstract

Alkaptonuric ochronosis is a heritable disorder of tyrosine metabolism, with various systemic abnormalities related to pigment deposition and degeneration of collagen and other tissues, including the heart and aorta, though no cerebrovascular abnormalities have been reported. The authors report a patient with alkaptonuric ochronosis and multiple intracranial aneurysms presenting with subarachnoid hemorrhage. The ruptured aneurysm was surgically treated, with a satisfactory outcome. In view of the well-known association of other connective tissue disorders with intracranial aneurysms, a potentially causal relationship is suggested between cerebral aneurysms and alkaptonuric ochronosis.

PMID:
2315833
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments

    Supplemental Content

    Loading ...
    Support Center