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Virology. 2013 Jan 20;435(2):329-40. doi: 10.1016/j.virol.2012.10.032. Epub 2012 Nov 13.

HIV-1 pre-mRNA commitment to Rev mediated export through PSF and Matrin 3.

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Laboratory of Molecular Virology, International Centre for Genetic Engineering and Biotechnology, Padriciano 99, 34012 Trieste, Italy.


Human immunodeficiency virus gene expression and replication are regulated at several levels. Incompletely spliced viral RNAs and full-length genomic RNA contain the RRE element and are bound by the viral trans-acting protein Rev to be transported out of the nucleus. Previously we found that the nuclear matrix protein MATR3 was a cofactor of Rev-mediated RNA export. Here we show that the pleiotropic protein PSF binds viral RNA and is associated with MATR3. PSF is involved in the maintenance of a pool of RNA available for Rev activity. However, while Rev and PSF bind the viral pre-mRNA at the site of viral transcription, MATR3 interacts at a subsequent step. We propose that PSF and MATR3 define a novel pathway for RRE-containing HIV-1 RNAs that is hijacked by the viral Rev protein.

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