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Clin Exp Obstet Gynecol. 2012;39(3):356-8.

The efficacy of dinoprostone vaginal insert for active management of premature rupture of membranes at term: a randomized controlled trial.

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  • 1Izmir Ataturk Training and Research Hospital, 1st Department of Gynecology and Obstetrics, Izmir, Turkey. drincimbezircioglu@yahoo.com

Abstract

PURPOSE:

To evaluate the efficacy and safety of the vaginal insertion of dinoprostone in terms of achieving cervical ripening, shortening the length of labor, and lowering the cesarean delivery rate for term pregnancies complicated with premature rupture of membranes.

METHODS:

A prospective, randomized, controlled trial enrolled 100 women with term pregnancies complicated with premature rupture of membranes. Each had a normal non stress test, unscarred uterus, a singleton pregnancy with cephalic presentation, and a Bishop score of less than 4. Patients were randomized to receive a 10 mg dinoprostone vaginal insert single dose or no medication. After cervical ripening, oxytocin induction was performed during labor for both the study and control group. Cervical ripening in the 12th hour, total delivery time and delivery mode were compared between the two groups.

RESULTS:

More often cervical ripening was obtained in the study group women who used dinoprostone vaginal inserts compared to the control group (p: 0.001). Latent phase of labor and total delivery time was shorter in the study group women than the control group (p: 0.022 and p: 0.026). There was no difference in terms of delivery mode and indication of section between study and control groups.

CONCLUSION:

The use of dinoprostone vaginal inserts in patients with term pregnancy of premature rupture of membranes reduced both the latent phase of labor and total delivery time without increasing the rate of cesarean section.

PMID:
23157043
[PubMed - indexed for MEDLINE]
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