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Nat Prod Commun. 2012 Oct;7(10):1331-2.

Chemoenzymatic synthesis of two new halogenated coumarin glycosides as potential antifungal agents.

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1
College of Pharmacy, Jinan University, 601 Huangpu Avenue West, Guangzhou 510632, China.

Abstract

Two new potential antifungal coumarin glycosides, 6-chlorocoumarin 7-O-beta-D-glucopyranoside (1) and 7-hydroxy-4-trifluoromethyl-coumarin 5-O-beta-D-glucopyranoside (2), were synthesized via enzyme-mediated glycosylation of the respective aglycone, 6-chloro-7-hydroxycoumarin and 5,7-dihydroxy-4-trifluoromethylcoumarin, using transgenic hairy roots of Polygonum multiflorum. Instead of application of the isolated enzyme and exogenous sugar donors, hairy roots of P. multiflorum were successfully adapted as a whole-cell biocatalyst.

PMID:
23157002
[Indexed for MEDLINE]
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