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J Pediatr Endocrinol Metab. 2012;25(7-8):733-9.

How much is enough? Evaluation of adrenal function in children who undergo growth hormone stimulation test.

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  • 1Ian Burr Division of Pediatric Endocrinology, Vanderbilt University Medical School, Nashville, TN 37232, USA. revi.mathew@vanderbilt.edu

Abstract

The objective was to determine the probability of receiving steroid treatment following an insulin tolerance test (ITT) for short-stature evaluation and to evaluate the utility of a subsequent cortrosyn stimulation test (CST) in determining adrenal sufficiency. We retrospectively analyzed the hypothalamic-pituitary-adrenal (HPA) axis evaluation in short-stature subjects during the 5-year period from January 2005 to December 2009. The probability of receiving steroid treatment was < 10% when the maximum cortisol concentration during an ITT was < 8.4 microg/dL. In the event of a suboptimal cortisol response during an ITT, only a single 1-microg CST is recommended for assessment of adrenal function.

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