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J Pediatr Endocrinol Metab. 2012;25(7-8):697-704.

Metabolic impact of a ketogenic diet compared to a hypocaloric diet in obese children and adolescents.

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1
Research Laboratory of the Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics, University of Patras School of Medicine, Patras, Achaea, Greece.

Abstract

BACKGROUND:

The effects of carbohydrate-restricted (ketogenic) diets on metabolic parameters in children have been incompletely assessed.

OBJECTIVE:

To compare the efficacy and metabolic impact of ketogenic and hypocaloric diets in obese children and adolescents.

SUBJECTS:

Fifty-eight obese subjects were placed on one of the two diets for 6 months.

METHODS:

Anthropometric measurements, body composition, oral glucose/insulin tolerance test, lipidemic profile, high molecular weight (HMW) adiponectin, whole-body insulin sensitivity index (WBISI), and homeostatic model assessment-insulin resistance (HOMA-IR) were determined before and after each diet.

RESULTS:

Both groups significantly reduced their weight, fat mass, waist circumference, fasting insulin, and HOMA-IR (p = 0.009 for ketogenic and p = 0.014 for hypocaloric), but the differences were greater in the ketogenic group. Both groups increased WBISI significantly, but only the ketogenic group increased HMW adiponectin significantly (p = 0.025).

CONCLUSIONS:

The ketogenic diet revealed more pronounced improvements in weight loss and metabolic parameters than the hypocaloric diet and may be a feasible and safe alternative for children's weight loss.

PMID:
23155696
DOI:
10.1515/jpem-2012-0131
[Indexed for MEDLINE]
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