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Plant Signal Behav. 2013 Feb;8(2):e22865. doi: 10.4161/psb.22865. Epub 2012 Nov 15.

CDC48 function during TMV infection: regulation of virus movement and replication by degradation?

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Botany; Department of Environmental Sciences; University of Basel; Basel, Switzerland.
Botany; Department of Environmental Sciences; University of Basel; Basel, Switzerland; Institut de Biologie Moléculaire des Plantes; UPR 2357 CNRS; Université de Strasbourg; Strasbourg, France.


Cell-division-cycle protein 48 (CDC48) is an essential, conserved ATP-driven chaperone in eukaryotic cells, which functions in diverse cellular processes including the targeting of misfolded and aggregated proteins for degradation via proteasomal and aggresomal-autophagic pathways. We recently demonstrated that plant CDC48 localizes to and interacts with Tobacco mosaic virus (TMV) movement protein (MP) in ER-associated viral protein inclusions. Our data suggest that CDC48 participates in the clearance of these viral protein inclusions in an ER-assisted protein degradation (ERAD)-like mechanism. As TMV MP-inclusions formed at late infection stages resemble aggresomes, we here propose that TMV MP enters both, ERAD-like and aggresomal pathways in its host cells and that CDC48 coordinates these processes. Moreover, as viruses often exploit host pathways for replication and spread, we propose a model in which CDC48 functions in the degradation pathway of overaccumulating viral protein and also actively participates in the regulation of TMV replication and cell-to-cell movement. 


ER-assisted protein degradation; Tobacco mosaic virus; aggresome; endoplasmic reticulum; microtubules; protein inclusion; replication complex; virus infection

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