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Nat Rev Microbiol. 2012 Dec;10(12):807-13. doi: 10.1038/nrmicro2893.

Structural vaccinology starts to deliver.

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1
Novartis Vaccines and Diagnostics Inc., 350 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.

Abstract

Following the impact of the genomics revolution on vaccine research and the development of reverse vaccinology, it was predicted that another new approach, structure-based antigen design, would become a driving force for vaccine innovation. Now, 5 years on, there are several examples of how structure-based design, or structural vaccinology, can deliver new vaccine antigens that were not possible before. Here, we discuss some of these examples and the contribution of structural vaccinology to our understanding of the protective epitopes of important bacterial and viral pathogens.

PMID:
23154260
DOI:
10.1038/nrmicro2893
[Indexed for MEDLINE]
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