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Behav Brain Res. 2013 Aug 15;251:113-24. doi: 10.1016/j.bbr.2012.10.037. Epub 2012 Nov 12.

Diagnosing autism in neurobiological research studies.

Author information

1
Weill-Cornell Medical College, Center for Autism and the Developing Brain, New York Presbyterian Hospital/Westchester Division, 21 Bloomingdale Road, White Plains, NY 10605, USA. rej2004@med.cornell.edu

Abstract

Autism spectrum disorder (ASD) is by definition a complex and heterogeneous disorder. Variation in factors such as developmental level, language ability and IQ further complicate the presentation of symptoms. Clinical research and basic science must continue to inform each other's questions to help address the heterogeneity inherent to the disorder. This review uses a clinical perspective to outline the common tools and best practices for diagnosing and characterizing ASD in a research setting. We discuss considerations for classifying research populations, including language ability and IQ and examine the advantages and disadvantages of different psychometric measurements. Ultimately, the contribution of multiple sources of data representing different perspectives is crucial for interpreting and understanding the ASD phenotype.

KEYWORDS:

ADI-R; ADOS; Autism; Diagnosis; Neurobiology; Neuroimaging

PMID:
23153932
PMCID:
PMC3711973
DOI:
10.1016/j.bbr.2012.10.037
[Indexed for MEDLINE]
Free PMC Article
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