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Cancer Cell. 2012 Nov 13;22(5):567-8. doi: 10.1016/j.ccr.2012.10.008.

BMP meets AML: induction of BMP signaling by a novel fusion gene promotes pediatric acute leukemia.

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Division of Hematology/Oncology, Northwestern University, University of Chicago, Chicago, IL 60637, USA.


In this issue of Cancer Cell, Gruber et al. report that a significant proportion of children with acute megakaryoblastic leukemia acquire a translocation that confers enhanced BMP signaling and promotes self-renewal of hematopoietic progenitors. This study presents novel therapeutic targets that may lead to improved therapies for this aggressive leukemia.

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