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Proc Natl Acad Sci U S A. 1990 Mar;87(6):2220-4.

Recombinant human bone morphogenetic protein induces bone formation.

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1
Genetics Institute, Cambridge, MA 02140.

Abstract

We have purified and characterized active recombinant human bone morphogenetic protein (BMP) 2A. Implantation of the recombinant protein in rats showed that a single BMP can induce bone formation in vivo. A dose-response and time-course study using the rat ectopic bone formation assay revealed that implantation of 0.5-115 micrograms of partially purified recombinant human BMP-2A resulted in cartilage by day 7 and bone formation by day 14. The time at which bone formation occurred was dependent on the amount of BMP-2A implanted; at high doses bone formation could be observed at 5 days. The cartilage- and bone-inductive activity of the recombinant BMP-2A is histologically indistinguishable from that of bone extracts. Thus, recombinant BMP-2A has therapeutic potential to promote de novo bone formation in humans.

PMID:
2315314
PMCID:
PMC53658
[Indexed for MEDLINE]
Free PMC Article
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