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Org Lett. 2012 Dec 7;14(23):5872-5. doi: 10.1021/ol302791x. Epub 2012 Nov 14.

An efficient and practical radiosynthesis of [11C]temozolomide.

Author information

1
Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA.

Erratum in

  • Org Lett. 2013 Feb 15;15(4):973.

Abstract

Temozolomide (TMZ) is a prodrug for an alkylating agent used for the treatment of malignant brain tumors. A positron emitting version, [(11)C]TMZ, has been utilized to help elucidate the mechanism and biodistribution of TMZ. Challenges in [(11)C]TMZ synthesis and reformulation make it difficult for routine production. A highly reproducible one-pot radiosynthesis of [(11)C]TMZ with a radiochemical yield of 17 ± 5% and ≥97% radiochemical purity is reported.

PMID:
23151019
PMCID:
PMC3979304
DOI:
10.1021/ol302791x
[Indexed for MEDLINE]
Free PMC Article
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