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J Clin Endocrinol Metab. 2013 Jan;98(1):314-21. doi: 10.1210/jc.2012-2599. Epub 2012 Nov 12.

Association of postburn fatty acids and triglycerides with clinical outcome in severely burned children.

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1
Shriners Hospitals for Children and Department of Surgery, University of Texas Medical Branch, Galveston, Texas 77555, USA.

Abstract

CONTEXT:

Free fatty acids (FFAs) and triglycerides (TGs) are altered postburn, but whether these alterations are associated with postburn outcomes is not clear.

OBJECTIVE:

The aim of the present study was to analyze lipid metabolic profiles in pediatric burn patients and to correlate these profiles with patient outcomes and hospital courses.

DESIGN AND SETTING:

We conducted a prospective cohort study at an academic pediatric hospital burn center.

PATIENTS:

Our study included 219 pediatric burn patients.

MAIN OUTCOME MEASURES:

Patients were stratified according to their plasma TG and FFA levels. Main patient outcomes, such as postburn morbidity and mortality, and clinical metabolic markers were analyzed.

RESULTS:

All groups were similar in demographics and injury characteristics. Patients with elevated TGs had significantly worse clinical outcomes associated with increased acute-phase protein synthesis indicating augmented inflammation and hypermetabolism, whereas increased FFAs did not seem to profoundly alter postburn outcomes.

CONCLUSIONS:

Elevated TGs, but not FFAs, postburn are associated with worsened organ function and clinical outcomes.

TRIAL REGISTRATION:

ClinicalTrials.gov NCT00675714.

PMID:
23150682
PMCID:
PMC3537101
DOI:
10.1210/jc.2012-2599
[Indexed for MEDLINE]
Free PMC Article
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