Format

Send to

Choose Destination
Subcell Biochem. 2013;61:455-78. doi: 10.1007/978-94-007-4525-4_20.

Epigenetic changes in inflammatory and autoimmune diseases.

Author information

1
Laboratory for Functional Genomics, Fondation Jean Dausset - Centre d'Etude du Polymorphisme Humain (CEPH), 27 rue Juliette Dodu, 75010, Paris, France.

Abstract

In higher eukaryotic organisms epigenetic modifications are crucial for proper chromatin folding and thereby proper regulation of gene expression. In the last years the involvement of aberrant epigenetic modifications in inflammatory and autoimmune diseases has been recognized and attracted significant interest. However, the epigenetic mechanisms underlying the different disease phenotypes are still poorly understood. As autoimmune and inflammatory diseases are at least partly T cell mediated, we will provide in this chapter an introduction to the epigenetics of T cell differentiation followed by a summary of the current knowledge on aberrant epigenetic modifications that dysfunctional T cells display in various diseases such as type 1 diabetes, rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, inflammatory bowel disease, and asthma.

PMID:
23150263
DOI:
10.1007/978-94-007-4525-4_20
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center