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J Pediatr. 2013 Apr;162(4):741-5. doi: 10.1016/j.jpeds.2012.10.001. Epub 2012 Nov 10.

Impact of gestational diabetes mellitus on pubertal changes in adiposity and metabolic profiles in Latino offspring.

Author information

1
Department of Nutritional Sciences, University of Texas, Austin, TX, USA. Jaimie.davis@austin.utexas.edu

Abstract

OBJECTIVE:

To examine the impact of maternal gestational diabetes mellitus (GDM) status on longitudinal changes in adiposity and metabolic variables in overweight Latino offspring (from age 8-20 years) across puberty.

STUDY DESIGN:

This longitudinal cohort of 210 overweight Latino children was measured annually for a period of 3 ± 1 years for Tanner stage through physical examination, adiposity by dual-energy X-ray absorptiometry and magnetic resonance imaging, lipids, and glucose and insulin action via the oral glucose tolerance test and frequently sampled intravenous glucose tolerance test. Linear mixed-effects modeling estimated the impact of maternal GDM status on baseline and changes in adiposity and metabolic variables across puberty.

RESULTS:

In our cohort, 22% of offspring were from GDM pregnancies. At baseline, the GDM offspring were heavier at birth, more likely to have a family history of type 2 diabetes, and less likely to have been breastfed (for any duration). Compared with the non-GDM offspring, the GDM offspring had greater increases in total body fat (+6.5% vs +4.5%; P = .03) and steeper declines in acute insulin response (-39% vs -17%; P < .001) and disposition index (-57% vs -35%; P < .001) across Tanner stages, independent of ethnicity, sex, breastfeeding status, family history of diabetes, and baseline and changes in body composition.

CONCLUSION:

These findings confirm the elevated risk for excess adiposity and type 2 diabetes in GDM offspring, and further underscore the need for interventions targeting Latino GDM and their offspring.

PMID:
23149173
PMCID:
PMC3578029
DOI:
10.1016/j.jpeds.2012.10.001
[Indexed for MEDLINE]
Free PMC Article
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